Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Selenium (as L-selenomethionine)
100 mcg
182%
Top Medical Research Studies
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
Read More
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
Most Useful Reviews
7.5
Prevents heart disease
5 people found this helpful
Selenium is a potent antioxidant that protects cells from free radicals. Excessive free radical formation due to smoking, alcohol, and stress leads to oxidative stress, damaging healthy cells and contributing to cardiovascular diseases. Studies indicate that a 50% increase in selenium levels in the blood correlates with a 24% reduction in coronary artery disease risk. It's also an anticarcinogen, proving effective against lung and breast cancer, and is vital for normal thyroid gland function, where selenium is most concentrated, playing a key role in hormone metabolism.
Read More
7.5
Antitumor effect noted
4 people found this helpful
Selenium supports the cardiovascular and endocrine systems, particularly in certain thyroid conditions. Its preventative antitumour effects are essential in today's ecological climate. Moreover, selenium promotes the beauty of hair, skin, and nails, and serves as a powerful antioxidant that safeguards our immune system, while also being important for vision.
Read More
6
Reduces disease risks
3 people found this helpful
Selenium is a crucial trace element that enhances immune system function, aids in blood cell production, and lowers the risk of cardiovascular diseases. It can also eliminate heavy metal salts from the body. Significantly, it aids in the absorption of iodine, thereby improving thyroid gland function.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
9
We explored how a high selenium diet impacts heart health, especially under stress conditions like systolic overload. Using male mice, we compared those on a high selenium diet with those on a normal diet.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
Read More
9
Selenium compound shows heart protection
We investigated the effects of a new selenium-containing compound, Se-SAHA, on heart failure caused by isoproterenol. Our study found that Se-SAHA helped protect heart cells from damage, reducing cardiac hypertrophy and fibrosis in lab models.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
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9
We investigated the use of a new selenium delivery system to combat radiation-induced heart disease, which is a serious concern for cancer patients undergoing thoracic radiation. Our innovative oral microcarriers showed remarkable effects in protecting heart cells from radiation damage by reducing harmful reactive oxygen species.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Prevents heart disease
5 people found this helpful
Selenium is a potent antioxidant that protects cells from free radicals. Excessive free radical formation due to smoking, alcohol, and stress leads to oxidative stress, damaging healthy cells and contributing to cardiovascular diseases. Studies indicate that a 50% increase in selenium levels in the blood correlates with a 24% reduction in coronary artery disease risk. It's also an anticarcinogen, proving effective against lung and breast cancer, and is vital for normal thyroid gland function, where selenium is most concentrated, playing a key role in hormone metabolism.
Read More
7.5
Antitumor effect noted
4 people found this helpful
Selenium supports the cardiovascular and endocrine systems, particularly in certain thyroid conditions. Its preventative antitumour effects are essential in today's ecological climate. Moreover, selenium promotes the beauty of hair, skin, and nails, and serves as a powerful antioxidant that safeguards our immune system, while also being important for vision.
Read More
6
Reduces disease risks
3 people found this helpful
Selenium is a crucial trace element that enhances immune system function, aids in blood cell production, and lowers the risk of cardiovascular diseases. It can also eliminate heavy metal salts from the body. Significantly, it aids in the absorption of iodine, thereby improving thyroid gland function.
Read More
7.5
Strengthens blood vessels
2 people found this helpful
Selenium plays a vital role in the immune system, combats ageing, and halts inflammatory processes. It bolsters blood vessels, safeguards the heart from damage, helps prevent viral mutations, and is essential for thyroid gland function. My husband and I take one tablet for three months, followed by a break; one can lasts for three months.
Read More
7.5
Good product value
A very good product that benefits the heart, it offers a reasonable price and effective results!
Read More
Frequently Asked Questions
7.5
Strengthens blood vessels
2 people found this helpful
Selenium plays a vital role in the immune system, combats ageing, and halts inflammatory processes. It bolsters blood vessels, safeguards the heart from damage, helps prevent viral mutations, and is essential for thyroid gland function. My husband and I take one tablet for three months, followed by a break; one can lasts for three months.
7.5
Boosts immunity
3 people found this helpful
Selenium is highly beneficial, acting as an antioxidant that boosts immunity and improves blood flow, thereby lowering the likelihood of cardiovascular disease. It regulates thyroid function, enhances fertility, alleviates asthma symptoms, stabilises the nervous system, and stimulates metabolic processes. Typically, ½ tablet suffices for maintenance, and a whole tablet addresses deficiencies.
7.5
Prevents heart disease
5 people found this helpful
Selenium is a potent antioxidant that protects cells from free radicals. Excessive free radical formation due to smoking, alcohol, and stress leads to oxidative stress, damaging healthy cells and contributing to cardiovascular diseases. Studies indicate that a 50% increase in selenium levels in the blood correlates with a 24% reduction in coronary artery disease risk. It's also an anticarcinogen, proving effective against lung and breast cancer, and is vital for normal thyroid gland function, where selenium is most concentrated, playing a key role in hormone metabolism.
6
Cleanses the body
Selenium is not only key to preserving youth but is also crucial for lipid, carbohydrate, and protein metabolism. Its benefits include improving thyroid gland function, strengthening the immune system, nervous system regulation, reducing tumour disease risks, detoxifying the body, hormonal regulation, enhancing digestion, lowering cardiovascular pathologies' likelihood, and improving skin and nail health while boosting tocopherol and iodine activity.
6
Reduces disease risks
3 people found this helpful
Selenium is a crucial trace element that enhances immune system function, aids in blood cell production, and lowers the risk of cardiovascular diseases. It can also eliminate heavy metal salts from the body. Significantly, it aids in the absorption of iodine, thereby improving thyroid gland function.
8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
9
We explored how a high selenium diet impacts heart health, especially under stress conditions like systolic overload. Using male mice, we compared those on a high selenium diet with those on a normal diet.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
7
We explored the impact of selenium on heart health, particularly concerning the toxic effects of cadmium. Using zebrafish as a model, we tested various doses and timings of selenium exposure to assess its effectiveness against cadmium-induced heart problems.
Interestingly, we observed that a pre-treatment with 50 µg/L of selenium could reduce heart edema and slow heart rate caused by low levels of cadmium. However, we also found that this benefit diminished with higher cadmium doses.
Our results underline the need for careful selenium dosing and timing for optimal protective effects against heavy metal toxicity in the heart.
Interestingly, we observed that a pre-treatment with 50 µg/L of selenium could reduce heart edema and slow heart rate caused by low levels of cadmium. However, we also found that this benefit diminished with higher cadmium doses.
Our results underline the need for careful selenium dosing and timing for optimal protective effects against heavy metal toxicity in the heart.
7
Selenium's Immunoregulatory Role in HF
By analyzing data from 2,328 heart failure patients, we examined the relationship between serum selenium levels, blood biomarkers, and gene expression profiles.
Our findings indicate that higher selenium concentrations may have a beneficial effect in heart failure, primarily through immunoregulation. This is evidenced by reduced levels of inflammatory cytokines when selenium was introduced in vitro.
Overall, while selenium could play a positive role, further research is necessary to clarify the underlying mechanisms and specific modulators involved.
Our findings indicate that higher selenium concentrations may have a beneficial effect in heart failure, primarily through immunoregulation. This is evidenced by reduced levels of inflammatory cytokines when selenium was introduced in vitro.
Overall, while selenium could play a positive role, further research is necessary to clarify the underlying mechanisms and specific modulators involved.
References
- Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. doi:10.1016/j.freeradbiomed.2025.03.004
- He X, Sun H, Zhao Y, Fu X, Wang M, et al. Association of environmental metallic and metalloid contaminants with cardiovascular and all-cause mortality: An umbrella review of systematic reviews and meta-analyses. Eur J Prev Cardiol. 2025. doi:10.1093/eurjpc/zwaf118
- Li T, Yang B, Liu X, Shi D, Wang Z, et al. Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction. Int J Nanomedicine. 2025;20:1843. doi:10.2147/IJN.S500810
- Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. doi:10.1016/j.biomaterials.2025.123119
- Chen Q, Wang WY, Xu QY, Dai YF, Zhu XY, et al. The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism. J Cell Mol Med. 2024;28:e70124. doi:10.1111/jcmm.70124
- Heuer RM, Falagan-Lotsch P, Okutsu J, Deperalto M, Koop RR, et al. Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio). Cardiovasc Toxicol. 2024;24:1287. doi:10.1007/s12012-024-09910-0
- Bhattarai U, Xu R, He X, Pan L, Niu Z, et al. High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure. Redox Biol. 2024;76:103325. doi:10.1016/j.redox.2024.103325
- Sun Y, Mao Q, Zhou D, Tian J, Du H, et al. Associations of multiple blood metals with cardiac structure and function: A cross-sectional study in a CAD population. Environ Pollut. 2024;360:124718. doi:10.1016/j.envpol.2024.124718
- Marhamati S, Younesian O, Mir SM, Hosseinzadeh S, Joshaghani HR, et al. The effects of high doses of selenium supplementation on mRNA and protein levels of cMLCK levels and total antioxidant capacity in rat heart tissue. Food Chem Toxicol. 2024;191:114886. doi:10.1016/j.fct.2024.114886
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. doi:10.2147/CIA.S461821
- Cheng T, Liu C, Wang Y, Li G, Feng L, et al. A novel histone deacetylase inhibitor Se-SAHA attenuates isoproterenol-induced heart failure via antioxidative stress and autophagy inhibition. Toxicol Appl Pharmacol. 2024;487:116957. doi:10.1016/j.taap.2024.116957
- Liu C, Wang W, Lai H, Chen Y, Li L, et al. Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease. Bioact Mater. 2024;37:393. doi:10.1016/j.bioactmat.2024.03.034
- Aryafar M, Mahdavi M, Shahzadi H, Ranjbar YR, Sohouli MH, et al. Association between dietary selenium and zinc intake and risk of dilated cardiomyopathy in children: a case-control study. BMC Pediatr. 2024;24:251. doi:10.1186/s12887-024-04706-1
- Karaye KM, Sa'idu H, Ishaq NA, Balarabe SA, Ahmed BG, et al. Selenium Deficiency as a Risk Factor for Peripartum Cardiomyopathy. West Afr J Med. 2024;41:209.
- Li SJ, Wang AW, Huang KL, Yang Y. Recent Advances on Selenium Nutrition and Keshan Disease. Int Heart J. 2024;65:173. doi:10.1536/ihj.23-628
- Al-Mubarak AA, Markousis Mavrogenis G, Guo X, De Bruyn M, Nath M, et al. Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes. Redox Biol. 2024;70:103046. doi:10.1016/j.redox.2024.103046
